abstract：:In this single-case research study, we examined the efficacy and acceptability of sertraline treatment in children diagnosed with selective mutism. We utilized a double-blind, placebo-controlled trial of sertraline within a replicated multiple baseline/across participants research design (n = 2; n = 3). Multiple metho...

journal_title：Journal of child and adolescent psychopharmacology

authors： Carlson JS,Kratochwill TR,Johnston HF

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this trial was to investigate the short-term safety and efficacy of quetiapine fumarate in the treatment of children and adolescents with autistic disorder (AD). METHOD:This was a 16-week, open-label trial that included 6 male subjects with a mean age of 10.9 +/- 3.3 years. All subjects met th...

journal_title：Journal of child and adolescent psychopharmacology

authors： Martin A,Koenig K,Scahill L,Bregman J

更新日期：1999-01-01 00:00:00

abstract：:This study examined the contributions of childhood symptom dimensions and aspects of methylphenidate (MPH) treatment to the prediction of young adult outcomes in boys who were referred to a child psychiatry outpatient clinic. They were diagnosed with hyperkinetic reaction of childhood/minimal brain dysfunction, and gi...

journal_title：Journal of child and adolescent psychopharmacology

authors： Paternite CE,Loney J,Salisbury H,Whaley MA

更新日期：1999-01-01 00:00:00

abstract：:A preliminary clinical observation suggests the possibility of changes in valproate level when coadministered with guanfacine. Two pediatric inpatients (8 and 9 years of age) were treated with valproic acid and guanfacine concurrently. In one child, when guanfacine was tapered and discontinued, the plasma valproate co...

journal_title：Journal of child and adolescent psychopharmacology

authors： Ambrosini PJ,Sheikh RM

更新日期：1998-01-01 00:00:00

abstract：:This article surveys the development of human hepatic P450 cytochromes (CYPs) involved in xenobiotic metabolism from the fetus through the life span and explores possible clinical consequences of developmental issues. These hepatic P450 CYPs come "on line" at different times during fetal and infant development, and ea...

journal_title：Journal of child and adolescent psychopharmacology

authors： Oesterheld JR

更新日期：1998-01-01 00:00:00

abstract：:Medication management of obsessive-compulsive disorder (OCD) has consisted of monotherapy with either clomipramine (CMI) or selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine, paroxetine, or sertraline. Frequently, OCD patients receiving monotherapy experience low treatment response rates and problema...

journal_title：Journal of child and adolescent psychopharmacology

authors： Figueroa Y,Rosenberg DR,Birmaher B,Keshavan MS

更新日期：1998-01-01 00:00:00

abstract：:Low concentrations of the neurotransmitter serotonin and its 5-hydroxyindoleacetic acid metabolite in the central nervous system have been associated with increased aggressive behavior in animals and humans. Controlled clinical trials of serotonin agonists in depressed adults have suggested that aggressive behavior is...

journal_title：Journal of child and adolescent psychopharmacology

authors： Constantino JN,Liberman M,Kincaid M

更新日期：1997-04-01 00:00:00

abstract：:Attention-deficit hyperactivity disorder (ADHD) and major depression are common ailments that can cause significant dysfunction throughout the life cycle. These two disorders may occur comorbidly. This case series describes 7 pediatric patients (aged 10-16 years) and 4 adults (aged 38-44 years) whose ADHD and comorbid...

journal_title：Journal of child and adolescent psychopharmacology

authors： Findling RL

更新日期：1996-10-01 00:00:00

abstract：:Urinary catecholamine excretion was assessed in 15 boys with attention-deficit/hyperactivity disorder (ADHD) and 16 normal controls during a defined physical and mental task. Dihydroxyphenylalanine, dopamine, norepinephrine (NE), epinephrine (EPI), 3,4-dihydroxyphenylacetic acid, and 3,4-dihydroxyphenylglycol (DOPEG) ...

journal_title：Journal of child and adolescent psychopharmacology

authors： Hanna GL,Ornitz EM,Hariharan M

更新日期：1996-04-01 00:00:00

abstract：:This single case reports an open trial of lamotrigine in the treatment of self-injurious behavior (SIB) and epilepsy in an 18-year-old female diagnosed with generalized seizure disorder, stereotypic movement disorder, and compulsive SIB in the context of profound mental retardation. Animal models of SIB suggest that t...

journal_title：Journal of child and adolescent psychopharmacology

authors： Davanzo PA,King BH

更新日期：1996-01-01 00:00:00

abstract：:ABSTRACT Clinical trials with a treatment duration of at least 3 months were reviewed to determine the effect of psychostimulants on the core symptoms of attention-deficit hyperactivity disorder (ADHD) and on its commonly associated features. Eighteen studies were identified: 17 were studies of methylphenidate, 1 was ...

journal_title：Journal of child and adolescent psychopharmacology

authors： Schachar R,Tannock R

更新日期：1993-07-01 00:00:00

abstract：:ABSTRACT A report of neuroleptic malignant syndrome (NMS) in an adolescent patient with bipolar disorder is presented, and findings from a literature review of 35 child and adolescent cases (presenting before age 19) are compared with the reported experience in adults. Fever, rigidity, altered mental status, and tachy...

journal_title：Journal of child and adolescent psychopharmacology

authors： Steingard R,Khan A,Gonzalez A,Herzog DB

更新日期：1992-10-01 00:00:00

abstract：:ABSTRACT Neuroleptic malignant syndrome (NMS) is a potentially fatal disorder associated with the use of neuroleptics. Clinical research on NMS to date has focused exclusively on adults, but increasing numbers of juvenile cases have been reported. Two cases of juvenile NMS treated by the authors are discussed to demon...

journal_title：Journal of child and adolescent psychopharmacology

authors： Latz SR,McCracken JT

更新日期：1992-07-01 00:00:00

abstract：:ABSTRACT Current concerns about antidepressant efficacy in children and adolescents are reminiscent of the history of adult studies. Such awareness should temper these concerns, especially in view of the enormous progress in the last two decades of studies of adult depression. A number of methodologie, nosologie, deve...

journal_title：Journal of child and adolescent psychopharmacology

authors： Jensen PS,Ryan ND,Prien R

更新日期：1992-04-01 00:00:00

abstract：:ABSTRACT The pertinent literature was reviewed on cardiovascular changes induced by psychostimulant medication treatment of hyperactive children. An assessment of 15 controlled studies using test doses of methylphenidate revealed a significant elevation of the resting heart rate in previously unmedicated children (mea...

journal_title：Journal of child and adolescent psychopharmacology

authors： Safer DJ

更新日期：1992-01-01 00:00:00

abstract：:ABSTRACT The sudden collapse and death in three prepubertal children during routine treatment with desipramine was recently reported in brief statements. Insufficient clinical information is available to infer a cause-and-effect relationship between the therapeutic use of desipramine and sudden death in these children...

journal_title：Journal of child and adolescent psychopharmacology

authors： Popper CW,Elliott GR

更新日期：1990-10-01 00:00:00